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ACE2, the first homolog of human angiotensin converting enzyme (ACE) discovered in 2000, is a zinc metalloproteinase, a type 1 transmembrane protein，whose encoding genes locates on the X chromosome. ACE2 was initially thought to be expressed only in the heart, kidney and testes, but was later found to be also widely expressed in the lungs, brain and digestive tract. In lung tissue, it is mainly distributed in type ⅱ alveolar cells, and a small amount of type I alveolar cells, airway epithelial cells, fibroblasts, endothelial cells and macrophages.
During viral infection, ACE2 is the membrane-binding receptor of coronavirus, which is related to the fusion and invasion process of virus and host cells. ACE2 is associated with acute lung injury caused by coronavirus, and one of the mechanisms is the down-regulation of ACE2 expression. From the perspective of the progression from virus infection to lung injury, ACE2 is not only an essential target of coronavirus infection, but also one of the key pathological factors leading to lung injury and lung failure in novel coronavirus population.
ACE2 can reduce the release of cytokines and inhibit cellular inflammation and fibrosis, including atherosclerosis, cerebral ischemia, obesity, nephritis, hepatitis, liver fibrosis, asthma and so on. ACE2 has protective and therapeutic effects on cardiovascular and cerebrovascular diseases, atherosclerosis and so on.
1 MACE2 - KO mice
Strain: C57BL/6 mice
Gene type: gene knockout mice
Novel coronavirus insensitive
Editing position:
mACE2 knockout mice aged 1-8 weeks are available
2 HACE2 OE mice
Strain: C57BL/6 mice
Gene type: transgenic mice; transfected ACE2 gene mice
Novel coronavirus sensitive
HACE2 transgenic mice aged 1-8 weeks are available
