Renal artery ligation model of hypertension

Renal artery ligation model of hypertension

Hypertension is a disease with persistently high blood pressure, which can cause stroke, heart disease, hemangioma, kidney failure and other diseases. Hypertension is a systemic disease characterized by elevated arterial pressure and accompanied by functional or organic changes in organs such as heart, blood vessels, brain and kidney.

Experimental animal: Beagles

Model making method:

After anesthesia, the renal artery connected to the abdominal aorta was separated, and about 30% of it was narrowed by ligation. It was expected that the blood pressure of the operation group would start to rise in 1-3 days and reach a stable and high level in 6 days.

Model identification:

Blood pressure monitoring: estimated to be (26.01 ±1.95) kPa, i.e. 195±14.6mmHg, and 18.03±1.34kPa, i.e. 135mmHg, for the control group

pplication: Mechanism study and efficacy evaluation of antihypertensive drugs.